Nature Neuroscience 9, 787 - 797 (2006)
Published online: 21 May 2006; | doi:10.1038/nn1705
Midline radial glia translocation and corpus callosum formation require FGF signalingKaren Müller Smith1, 4, Yasushi Ohkubo1, 4, Maria Elisabetta Maragnoli1, Mladen-Roko Ra in2, 3, Michael L Schwartz2, Nenad  estan2, 3
& Flora M Vaccarino1, 21
Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA. 2
Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA. 3
Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06520, USA. 4
These authors contributed equally to this work.
Correspondence should be addressed to Flora M Vaccarino flora.vaccarino@yale.edu Midline astroglia in the cerebral cortex develop earlier than other astrocytes through mechanisms that are still unknown. We show that radial glia in dorsomedial cortex retract their apical endfeet at midneurogenesis and translocate to the overlaying pia, forming the indusium griseum. These cells require the fibroblast growth factor receptor 1 (Fgfr1) gene for their precocious somal translocation to the dorsal midline, as demonstrated by inactivating the Fgfr1 gene in radial glial cells and by RNAi knockdown of Fgfr1 in vivo. Dysfunctional astroglial migration underlies the callosal dysgenesis in conditional Fgfr1 knockout mice, suggesting that precise targeting of astroglia to the cortex has unexpected roles in axon guidance. FGF signaling is sufficient to induce somal translocation of radial glial cells throughout the cortex; furthermore, the targeting of astroglia to dorsolateral cortex requires FGFr2 signaling after neurogenesis. Hence, FGFs have an important role in the transition from radial glia to astrocytes by stimulating somal translocation of radial glial cells.
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