Nature Neuroscience 9, 779 - 786 (2006)
Published online: 14 May 2006; | doi:10.1038/nn1704
Doublecortin maintains bipolar shape and nuclear translocation during migration in the adult forebrainHiroyuki Koizumi, Holden Higginbotham, Tiffany Poon, Teruyuki Tanaka, Brendan C Brinkman
& Joseph G Gleeson
Neurogenetics Laboratory, Department of Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Correspondence should be addressed to Joseph G Gleeson jogleeson@ucsd.edu The ability of the mature mammalian nervous system to continually produce neuronal precursors is of considerable importance, as manipulation of this process might one day permit the replacement of cells lost as a result of injury or disease. In mammals, the anterior subventricular zone (SVZa) region is one of the primary sites of adult neurogenesis. Here we show that doublecortin (DCX), a widely used marker for newly generated neurons, when deleted in mice results in a severe morphological defect in the rostral migratory stream and delayed neuronal migration that is independent of direction or responsiveness to Slit chemorepulsion. DCX is required for nuclear translocation and maintenance of bipolar morphology during migration of these cells. Our data identifies a critical function for DCX in the movement of newly generated neurons in the adult brain.
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