Nature Neuroscience 9, 729 - 731 (2006)
Published online: 30 April 2006; | doi:10.1038/nn1696
Hippocampal neurogenesis is not required for behavioral effects of environmental enrichmentDar Meshi1, 6, Michael R Drew2, 3, 6, Michael Saxe2, Mark S Ansorge4, Denis David2, 5, Luca Santarelli2, Chariklia Malapani3, Holly Moore4
& René Hen2, 41
Department of Biological Sciences, Columbia University, New York, New York 10027, USA. 2
Center for Neurobiology and Behavior, Columbia University, 1051 Riverside Drive, Unit 87, New York, New York 10032, USA. 3
Biopsychology Unit, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 50, New York, New York 10032, USA. 4
Department of Psychiatry, Columbia University, 1051 Riverside Drive, Unit 14, New York, New York 10032, USA. 5
Faculté de Pharmacie, Université Paris-Sud, Tour D1, 2e etage, EA3544, Chatenay-Malabry Cedex, F-92296, France. 6
These authors contributed equally to this work.
Correspondence should be addressed to René Hen rh95@columbia.edu Environmental enrichment increases adult hippocampal neurogenesis and alters hippocampal-dependent behavior in rodents. To investigate a causal link between these two observations, we analyzed the effect of enrichment on spatial learning and anxiety-like behavior while blocking adult hippocampal neurogenesis. We report that environmental enrichment alters behavior in mice regardless of their hippocampal neurogenic capability, providing evidence that the newborn cells do not mediate these effects of enrichment.
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