Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels

Haoxing Xu, Markus Delling, Janice C Jun & David E Clapham

Supplementary Fig. 1 (pdf 524K)
Specificity of mTRPV3 polyclonal antibody.

Supplementary Fig. 2 (pdf 2M)
TRPV3 expression in the epithelia surrounding taste buds of circumvallate papillae.

Supplementary Fig. 3 (pdf 20K)
Structures of a family of plant-derived phenol-containing compounds.

Supplementary Fig. 4 (pdf 44K)
Carvacrol increases [Ca²⁺]_i in rat tongue epithelial cells.

Supplementary Fig. 5 (pdf 1M)
Carvacrol does not activate TRPV1, TRPV2, TRPV4, or TRPM8.

Supplementary Fig. 6 (pdf 812K)
Mouse 308 keratinocytes express TRPV3 and display TRPV3-like (I _{TRPV3_L}) currents.

Supplementary Fig. 7 (pdf 2M)
Eugenol activates TRPV3 but not TRPV2 or TRPV4.

Supplementary Fig. 8 (pdf 788K)
Sensitization of I _TRPV3 by stimulation of G protein-linked, PLC-coupled receptors.

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