Abstract
Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs ∼25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.
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References
Shi, S., Hayashi, Y., Esteban, J.A. & Malinow, R. Cell 105, 331–343 (2001).
Hayashi, Y. et al. Science 287, 2262–2267 (2000).
Terashima, A. et al. J. Neurosci. 24, 5381–5390 (2004).
Kumar, S.S., Bacci, A., Kharazia, V. & Huguenard, J.R. J. Neurosci. 22, 3005–3015 (2002).
Ju, W. et al. Nat. Neurosci. 7, 244–253 (2004).
Bowie, D. & Mayer, M.L. Neuron 15, 453–462 (1995).
Kamboj, S.K., Swanson, G.T. & Cull-Candy, S.G. J. Physiol. (Lond.) 486, 297–303 (1995).
Koh, D.S., Burnashev, N. & Jonas, P. J. Physiol. (Lond.) 486, 305–312 (1995).
Toth, K. & McBain, C.J. Nat. Neurosci. 1, 572–578 (1998).
Toth, K., Suares, G., Lawrence, J.J., Philips-Tansey, E. & McBain, C.J. J. Neurosci. 20, 8279–8289 (2000).
Bagal, A.A., Kao, J.P., Tang, C.M. & Thompson, S.M. Proc. Natl. Acad. Sci. USA 102, 14434–14439 (2005).
Bellone, C. & Luscher, C. Eur. J. Neurosci. 21, 1280–1288 (2005).
Liu, S.Q. & Cull-Candy, S.G. Nature 405, 454–458 (2000).
Malenka, R.C. & Bear, M.F. Neuron 44, 5–21 (2004).
Frey, U. & Morris, R.G. Nature 385, 533–536 (1997).
Acknowledgements
Supported by the Wellcome Trust (A.T., G.L.C. and J.T.R.I.), the Medical Research Council UK (G.L.C. and J.T.R.I.), the National Institute of Neurological Disorders and Stroke Intramural Program (J.T.R.I.) and the National Institute of Child Health and Human Development Intramural Program (K.A.P. and C.J.M.)
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Supplementary Fig. 1
LTP is NMDA receptor-dependent and PhTx blocks potentiated EPSCs when applied three minutes after LTP induction. (PDF 2037 kb)
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Plant, K., Pelkey, K., Bortolotto, Z. et al. Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation. Nat Neurosci 9, 602–604 (2006). https://doi.org/10.1038/nn1678
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DOI: https://doi.org/10.1038/nn1678
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