Nature Neuroscience 9, 602 - 604 (2006)
Published online: 2 April 2006; | doi:10.1038/nn1678
Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiationKaren Plant1, 4, Kenneth A Pelkey2, 4, Zuner A Bortolotto1, Daiju Morita1, 3, Akira Terashima1, Chris J McBain2, Graham L Collingridge1
& John T R Isaac1, 31
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, UK. 2
Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, 35 Convent Drive, Bethesda, Maryland 20892, USA. 3
Developmental Synaptic Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, Maryland 20892, USA. 4
These authors contributed equally to this work.
Correspondence should be addressed to John T R Isaac isaacj@ninds.nih.gov Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs  25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.
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