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Brief Communication
Nature Neuroscience 9, 475–477 (1 April 2006) | doi:10.1038/nn1661
CREB modulates excitability of nucleus accumbens neurons
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Abstract
Drugs of abuse cause activation of the cyclic AMP response element binding protein (CREB) in the nucleus accumbens (NAc). Expression of active CREB in rat NAc medium spiny neurons (MSNs) increased their excitability, whereas dominant-negative CREB had the opposite effect.
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