Both menthol and cool temperatures activate the cation channel TRPM8, but whether they do so via distinct domains was unclear. A new paper shows that activation of TRPM8 by these two stimuli can be separated.
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Jessica Iannuzzi
References
Bandell, M. et al. Nat. Neurosci. 9, 493–500 (2006).
Montell, C. Sci. STKE 2005, re3 (2005).
McKemy, D.D., Nenhausser, W.M. & Julius, D. Nature 416, 52–58 (2002).
Peier, A. et al. Cell 108, 705–715 (2002).
Caterina, M.J. et al. Nature 389, 816–824 (1997).
Liu, B. & Qin, F. J. Neurosci. 25, 1674–1681 (2005).
Rohács, T., Lopes, C.M., Michailidis, I. & Logothetis, D.E. Nat. Neurosci. 8, 626–634 (2005).
Voets, T. et al. Nature 430, 748–754 (2004).
Brauchi, S., Orio, P. & Latorre, R. Proc. Natl. Acad. Sci. USA 101, 15494–15499 (2004).
Smith, G.D. et al. Nature 418, 186–190 (2002).
Xu, H. et al. Nature 418, 181–186 (2002).
Moqrich, A. et al. Science 307, 1468–1472 (2005).
Jordt, S.E. et al. Nature 427, 260–265 (2004).
Bandell, M. et al. Neuron 41, 849–857 (2004).
Story, G.M. et al. Cell 112, 819–829 (2003).
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Montell, C. A mint of mutations in TRPM8 leads to cool results. Nat Neurosci 9, 466–468 (2006). https://doi.org/10.1038/nn0406-466
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DOI: https://doi.org/10.1038/nn0406-466
