Brief Communication abstract


Nature Neuroscience 9, 478 - 480 (2006)
Published online: 12 March 2006 | doi:10.1038/nn1667

Neuronal activity determines the protein synthesis dependence of long-term potentiation

Rosalina Fonseca1, U Valentin Nägerl1 & Tobias Bonhoeffer1

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Long-term potentiation (LTP) is generally divided into two phases, early (E-) and late (L-) LTP, of which only L-LTP is thought to depend on protein synthesis. Here we report that E-LTP can also be dependent on protein synthesis at higher levels of synaptic activation. Moreover, we show that the requirement for protein synthesis during L-LTP extends beyond the early induction phase and that it depends on synaptic stimulation. This suggests that the level of neuronal activity is a crucial determinant for the role of protein synthesis in E- and L-LTP.

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  1. Department of Cellular and Systems Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz 18, D-82152 München-Martinsried, Germany.

Correspondence to: Tobias Bonhoeffer1 e-mail: tobias.bonhoeffer@neuro.mpg.de



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