Long-term potentiation (LTP) is generally divided into two phases,
early (E-) and late (L-) LTP, of which only L-LTP is thought to
depend on protein synthesis. Here we report that E-LTP can also be
dependent on protein synthesis at higher levels of synaptic
activation. Moreover, we show that the requirement for protein
synthesis during L-LTP extends beyond the early induction phase and
that it depends on synaptic stimulation. This suggests that the level
of neuronal activity is a crucial determinant for the role of protein
synthesis in E- and L-LTP.
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