Nature Neuroscience 9, 475 - 477 (2006)
Published online: 5 March 2006; | doi:10.1038/nn1661
CREB modulates excitability of nucleus accumbens neuronsYan Dong1, Thomas Green2, Daniel Saal1, Helene Marie1, Rachael Neve3, Eric J Nestler2
& Robert C Malenka11
Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California 94304, USA. 2
Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. 3
Department of Genetics and McClean Hospital, Harvard University, Cambridge, Massachusetts 02478, USA.
Correspondence should be addressed to Robert C Malenka malenka@stanford.edu Drugs of abuse cause activation of the cyclic AMP response element binding protein (CREB) in the nucleus accumbens (NAc). Expression of active CREB in rat NAc medium spiny neurons (MSNs) increased their excitability, whereas dominant-negative CREB had the opposite effect. Decreasing excitability of NAc MSNs in vivo by overexpression of potassium channels enhanced locomotor responses to cocaine, suggesting that the increased NAc MSN excitability caused by CREB helped to limit behavioral sensitivity to cocaine.
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