A mint of mutations in TRPM8 leads to cool results
Craig Montell
Craig Montell is in the Departments of Biological Chemistry and Neuroscience, The Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, Maryland 21205, USA. cmontell@jhmi.edu
Both menthol and cool temperatures activate the cation channel TRPM8, but whether they do so via distinct domains was unclear. A new paper shows that activation of TRPM8 by these two stimuli can be separated.
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