Nature Neuroscience 9, 465 - 466 (2006)
doi:10.1038/nn0406-465
Even chromatin gets the bluesSteven E Hyman
Steven Hyman is in the Department of Neurobiology, Harvard Medical School, Massachusetts Hall, Cambridge, Massachusetts 02138, USA. seh@harvard.edu
Antidepressants take a few weeks to act, and their effects can extend for months after the drugs are discontinued. Tsankova et al. suggest a possible molecular basis for these effects, by showing that stress and the antidepressant imipramine induce modifications of chromatin to produce more or less repressive states for gene expression.
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