Nature Neuroscience 9, 299 - 300 (2006)
doi:10.1038/nn0306-299
PEDF: bridging neurovascular interactions in the stem cell nicheKevin Pumiglia
& Sally Temple
Kevin Pumiglia is at the Center for Cell Biology and Cancer and Sally Temple is at the Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA. temples@mail.amc.edu
Stem cells are defined by their ability to self-renew. Adult brain stem cells divide slowly, and it is unclear how their division is regulated. A new study identifies PEDF as a growth factor that promotes adult stem cell self-renewal.
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