Thomas Otis is in the Department of Neurobiology and Joanna Jen is in the Department of Neurology, Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA. otist@ucla.edu
Many neurons, particularly inhibitory neurons in motor areas, express ion channels that cause them to fire rapidly and regularly without input. A paper now presents evidence that an inherited ataxia due to mutation in a P/Q-type calcium channel gene results from compromised pacemaking in cerebellar Purkinje neurons, suggesting a possible therapy.
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