Nature Neuroscience 9, 157 - 158 (2006)
doi:10.1038/nn0206-157
Indirect-pathway neurons lose their spines in Parkinson diseaseCharles R Gerfen
The author is at the Laboratory of Systems Neuroscience, National Institute of Mental Health, 35 Convent Drive, 3A-1000, Bethesda, Maryland 20892, USA.
gerfenc@mail.nih.gov
The Cav1.3 calcium channel is found on striatopallidal neurons expressing the D2 dopamine receptor. A new study finds that in an animal model of Parkinson disease, this channel is involved in degeneration of dendritic spines on striatal projection neurons.
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