The authors are in the Department of Pathology and the Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, 630 W. 168th St., New York, New York 10032, USA. jeg5@columbia.edu
The exact embryonic origins of forebrain oligodendrocytes have been unclear. A new study addresses the question with elegant genetic fate mapping, and concludes that oligodendrocytes are generated in three distinct waves. Oligodendrocytes from later waves eventually replaced those generated in earlier waves, but if one wave was lost, the other waves could compensate.
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