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Brief Communication

Nature Neuroscience 9, 1477–1478 (1 December 2006) | doi:10.1038/nn1795

A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms

Jeremy Hall , Heather C Whalley , Dominic E Job , Ben J Baig , Andrew M McIntosh , Kathryn L Evans , Pippa A Thomson , David J Porteous , David G Cunningham-Owens , Eve C Johnstone & Stephen M Lawrie

NRG1, encoding neuregulin 1, is a susceptibility gene for schizophrenia, but no functional mutation causally related to the disorder has yet been identified. Here we investigate the effects of a variant in the human NRG1 promoter region in subjects at high risk of schizophrenia.