Nature Neuroscience
- 9, 1474 - 1476 (2006)
Published online: 19 November 2006; | doi:10.1038/nn1807
Cochlear efferent feedback balances interaural sensitivityKeith N Darrow1, 2, Stéphane F Maison1, 3 & M Charles Liberman1, 2, 31
Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St., Boston, Massachusetts 02114, USA. 2
Program in Speech and Hearing Bioscience and Technology, Division of Health Science and Technology, Harvard & MIT, Cambridge, Massachusetts 02139, USA. 3
Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Correspondence should be addressed to M Charles Liberman Charles_Liberman@meei.harvard.edu Neurons in the lateral superior olive (LSO) compute sound location based on differences in interaural intensity, coded in ascending signals from the two cochleas. Unilateral destruction of the neuronal feedback from the LSO to the cochlea, the lateral olivocochlear efferents, disrupted the normal interaural correlation in response amplitudes to sounds of equal intensity. Thus, lateral olivocochlear feedback maintains the binaural balance in neural excitability required for accurate localization of sounds in space.
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