Nature Neuroscience
- 9, 1477 - 1478 (2006)
Published online: 29 October 2006; | doi:10.1038/nn1795
A neuregulin 1 variant associated with abnormal cortical function and psychotic symptomsJeremy Hall1, Heather C Whalley1, Dominic E Job1, Ben J Baig1, Andrew M McIntosh1, Kathryn L Evans2, Pippa A Thomson2, David J Porteous2, David G Cunningham-Owens1, Eve C Johnstone1 & Stephen M Lawrie11
Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, UK. 2
Section of Medical Genetics, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.
Correspondence should be addressed to Jeremy Hall jhall5@staffmail.ed.ac.uk
NRG1, encoding neuregulin 1, is a susceptibility gene for schizophrenia, but no functional mutation causally related to the disorder has yet been identified. Here we investigate the effects of a variant in the human NRG1 promoter region in subjects at high risk of schizophrenia. We show that this variant is associated with (i) decreased activation of frontal and temporal lobe regions, (ii) increased development of psychotic symptoms and (iii) decreased premorbid IQ.
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