An inhibitor of glycolysis is shown to have antiepileptic effects in the rat kindling model, possibly through NADH-dependent regulation of gene expression. This may explain how the 'ketogenic diet' treatment works.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
Purchase on Springer Link
Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Engel, J. & Pedley, T. in Epilepsy: A Comprehensive Textbook 1339–1342 (Lippincott-Raven, Philadelphia, 1997).
Garriga-Canut, M. et al. Nat. Neurosci. 9, 1382–1387 (2006).
He, X. et al. Neuron 43, 31–42 (2004).
Chong, J.A. et al. Cell 80, 949–957 (1995).
Schoenherr, C.J. & Anderson, D.J. Science 267, 1360–1363 (1995).
Magistretti, P.J. J. Exp. Biol. 209, 2304–2311 (2006).
Li, Z. et al. Cell 119, 873–887 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Huang, Y., McNamara, J. Inhibiting glycolysis to reduce seizures: how it might work. Nat Neurosci 9, 1351–1352 (2006). https://doi.org/10.1038/nn1106-1351
Issue Date:
DOI: https://doi.org/10.1038/nn1106-1351
This article is cited by
-
NRSF: an Angel or a Devil in Neurogenesis and Neurological Diseases
Journal of Molecular Neuroscience (2015)