Presenilins and Alzheimer disease: the calcium conspiracy
Gopal Thinakaran & Sangram S Sisodia
The authors are at the Department of Neurobiology, Pharmacology & Physiology, University of Chicago, Chicago, Illinois 60637, USA. gopal@uchicago.edu or ssisodia@bsd.uchicago.edu
Most early-onset familial Alzheimer disease is caused by presenilin mutations. A recent paper reports that the presenilins act as calcium leak channels in the endoplasmic reticulum and thus may regulate intracellular calcium homeostasis.
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