Nature Neuroscience
- 9, 1351 - 1352 (2006)
doi:10.1038/nn1106-1351
Inhibiting glycolysis to reduce seizures: how it might workYang Zhong Huang & James O McNamara
The authors are at the Department of Neurobiology, Department of Medicine (Neurology) and Center for Translational Neuroscience, Duke University Medical Center, Durham, North Carolina 27710, USA. jmc@neuro.duke.edu
An inhibitor of glycolysis is shown to have antiepileptic effects in the rat kindling model, possibly through NADH-dependent regulation of gene expression. This may explain how the 'ketogenic diet' treatment works.
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