Nature Neuroscience
- 9, 1205 - 1206 (2006)
doi:10.1038/nn1006-1205
Intercellular miscommunication in polyglutamine pathogenesisChristopher A Ross1 & Don W Cleveland21
Christopher A. Ross is in the Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, CMSC 8-121, 600 North Wolfe Street, Baltimore, Maryland 21287, USA. caross@jhu.edu
2
Don W. Cleveland is at the Ludwig Institute, Department of Neurosciences, University of California San Diego, 3080 CMM East 9500 Gilman Drive, La Jolla, California 92093-0670, USA. A new paper demonstrates that polyglutamine pathogenesis in spinocerebellar ataxia need not be cell autonomous. Mutant ataxin-7 expression restricted to Bergmann glia was sufficient to cause Purkinje cell degeneration and neuronal pathology.
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