Nature Neuroscience 9, 23 - 25 (2005)
Published online: 11 December 2005; | doi:10.1038/nn1616
Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain responsesMichael D Fox1, Abraham Z Snyder1, 2, Jeffrey M Zacks1, 3
& Marcus E Raichle1, 2, 4, 51
Department of Radiology, Washington University in St. Louis, St. Louis, Missouri 63110, USA. 2
Department of Neurology, Washington University in St. Louis, St. Louis, Missouri 63110, USA. 3
Department of Psychology, Washington University in St. Louis, St. Louis, Missouri 63110, USA. 4
Departments of Anatomy and Neurobiology, Washington University in St. Louis, St. Louis, Missouri 63110, USA. 5
Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63110, USA.
Correspondence should be addressed to Michael D Fox foxm@npg.wustl.edu Trial-to-trial variability in the blood oxygen level–dependent (BOLD) response of functional magnetic resonance imaging has been shown to be relevant to human perception and behavior, but the sources of this variability remain unknown. We demonstrate that coherent spontaneous fluctuations in human brain activity account for a significant fraction of the variability in measured event-related BOLD responses and that spontaneous and task-related activity are linearly superimposed in the human brain.
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