Nature Neuroscience 9, 8 - 10 (2006)
doi:10.1038/nn0106-8
Internalizing channels: a mechanism to control pain?Diane Lipscombe
& Jesica Raingo
The authors are in the Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA. diane_lipscombe@brown.edu
The opioid receptor–like receptor inhibits the Cav2.2 calcium channel even without the receptor ligand, nociceptin. A new study finds that long-term exposure to nociceptin causes internalization of the receptor-channel complex.
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