Damaging secretions: chromogranins team up with mutant SOD1
Michael Sendtner
The author is at the Institute of Clinical Neurobiology, University of Wuerzburg, Josef-Schneider-Str. 11, 97080 Wuerzburg, Germany. sendtner@mail.uni-wuerzburg.de
A familial form of ALS is caused by mutations in the superoxide dismutase (SOD1) gene. A new paper shows that mutant SOD1 binds chromogranins in secretory vesicles and that its release promotes microgliosis and motor neuron death.
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