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Brief Communication
Nature Neuroscience  8, 1139 - 1141 (2005)
Published online: 7 August 2005; | doi:10.1038/nn1521

Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus

Judit K Makara, Marco Mor, Darren Fegley, Szilárd I Szabó, Satish Kathuria, Giuseppe Astarita, Andrea Duranti, Andrea Tontini, Giorgio Tarzia, Silvia Rivara, Tamás F Freund & Daniele Piomelli

Supplementary Fig. 1 (pdf 185K)
The effect of URB602 on DSI is mediated by CB1 receptors.

Supplementary Fig. 2 (pdf 636K)
URB602 does not affect depolarization-evoked Ca2+ transients in hippocampal CA1 pyramidal neurons.

Supplementary Fig. 3 (pdf 563K)
URB754 and URB602 do not inhibit FAAH activity in rat forebrain slice cultures.

Supplementary Fig. 4 (pdf 313K)
Effects of a high concentration of URB754 (3 muM) on hippocampal DSI.

Supplementary Table 1 (pdf 39K)
Kinetic analysis of the effects of URB754 on the activity of recombinant rat brain MGL expressed in HeLa cells.

Supplementary Methods (pdf 129K)


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Nature Neuroscience
ISSN: 1097-6256
EISSN: 1546-1726
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