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Brief Communication
Nature Neuroscience 8, 1139–1141 (1 September 2005) | doi:10.1038/nn1521
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
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Abstract
The functions of 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid found in the brain, remain largely unknown. Here we show that two previously unknown inhibitors of monoacylglycerol lipase, a presynaptic enzyme that hydrolyzes 2-AG, increase 2-AG levels and enhance retrograde signaling from pyramidal neurons to GABAergic terminals in the hippocampus.
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