Nature Neuroscience
8, 1136 - 1137 (2005)
doi:10.1038/nn0905-1136
Pathological tau: a loss of normal function or a gain in toxicity?John Q Trojanowski
& Virginia M-Y Lee
John Trojanowski and Virginia Lee are at the Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, and the Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. trojanow@mail.med.upenn.edu
Neurofibrillary tangles, composed of tau protein, are a central feature of Alzheimer disease. A new paper challenges the idea that these tau inclusions alone cause disease by showing that they can be dissociated from memory impairment and neuronal loss.
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