Arnold Kriegstein is at the Department of Neurology and the Program in Developmental and Stem Cell Biology, University of California, San Francisco, California 94143, USA. kriegsteina@stemcell.ucsf.edu
In the adult brain, new neurons are generated from neural stem cells residing in the subventricular zone. Newborn neuroblasts release the transmitter GABA, which reduces the proliferation of stem cells—and thereby neurogenesis—by a nonsynaptic mechanism.
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