Nature Neuroscience
8, 985 - 987 (2005)
Published online: 10 July 2005; | doi:10.1038/nn1432
Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1Chong-Hyun Kim1, Kogo Takamiya1, Ronald S Petralia2, Rita Sattler1, Sandy Yu1, Weiguo Zhou3, Robert Kalb3, Robert Wenthold2
& Richard Huganir11
Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University, Baltimore, Maryland 21205, USA. 2
Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institute of Health, Bethesda, Maryland 20892, USA. 3
Children's Hospital of Philadelphia, Joseph Strokes, Jr. Research Institute, ARC 814, 3615 Civic Center Blvd., Philadelphia, Pennsylvania, 19104, USA.
Correspondence should be addressed to Richard Huganir rhuganir@jhmi.edu The C-terminal PDZ ligand of the AMPA receptor GluR1 subunit may be important for expression of CA1 hippocampal long-term potentiation. To test this directly in vivo, we generated a knock-in mouse lacking the last seven residues of GluR1, comprising the PDZ ligand. This deletion did not affect basal GluR1 synaptic localization, basal synaptic transmission, long-term potentiation or long-term depression, indicating that the ligand is not required for CA1 hippocampal synaptic plasticity.
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