Pasko Rakic is in the Department of Neurobiology and the Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06511, USA. pasko.rakic@yale.edu
Cerebral cortex size in individuals and species is determined by cortical progenitor mitosis and death during embryogenesis. EphA signaling—important in axon guidance and patterning—also seems to be critical in regulating the survival of cortex progenitors.
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