Nature Neuroscience
8, 979 - 981 (2005)
doi:10.1038/nn0805-979
Beyond migration: Dlx1 regulates interneuron differentiationCarl Wonders
& Stewart Anderson
Carl Wonders and Stewart Anderson are at the Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA. saa2007@med.cornell.edu
A new paper shows that the transcription factor Dlx1, known to be involved in neuronal migration, is also necessary for interneuron survival. Mice lacking Dlx1 show subtype-specific loss of interneurons, a reduction in inhibitory currents and generalized seizures.
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