Rudolph E. Tanzi is at the Genetics and Aging Research Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA. tanzi@helix.mgh.harvard.edu
A peptide is linked to Alzheimer pathology, but its toxic mechanism remains unclear. New work shows that A leads to internalization of NMDA receptors, reducing their availability at synapses. The authors also suggest a molecular mechanism for this endocytosis.
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hypothesis of Alzheimer disease
peptide is linked to Alzheimer pathology, but its toxic mechanism remains unclear. New work shows that A
