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Brief Communication

Nature Neuroscience 8, 858–859 (1 July 2005) | doi:10.1038/nn1491

Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine

Zhi-Li Huang , Wei-Min Qu , Naomi Eguchi , Jiang-Fan Chen , Michael A Schwarzschild , Bertil B Fredholm , Yoshihiro Urade & Osamu Hayaishi

Caffeine, a component of tea, coffee and cola, induces wakefulness. It binds to adenosine A1 and A2A receptors as an antagonist, but the receptor subtype mediating caffeine-induced wakefulness remains unclear.