Nature Neuroscience8, 853 - 854 (2005)
Published online: 29 May 2005; | doi:10.1038/nn1476
Dominant role of the GluR2 subunit in regulation of AMPA receptors by CaMKII
Michael C Oh
& Victor A Derkach
Vollum Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon, 97239, USA.
Correspondence should be addressed to Victor A Derkach derkachv@ohsu.edu
GluR1 and GluR2 subunits compose AMPA receptors (AMPARs) in the mature hippocampus, and both the GluR1 subunit and Ca2+/calmodulin-dependent protein kinase II (CaMKII) are required for synaptic plasticity, memory and learning. Although GluR1 phosphorylation by CaMKII is preserved, the functional regulation of AMPARs by phosphorylation is lost in the presence of the GluR2 subunit. Our findings define a previously unknown, dominant role of the GluR2 subunit in signaling mediated by CaMKII at AMPARs.
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