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Review
Nature Neuroscience  8, 709 - 715 (2005)
Published online: 25 May 2005; | doi:10.1038/nn1475


There is an Erratum (October 2005) associated with this Review.

Notch signaling in the mammalian central nervous system: insights from mouse mutants

Keejung Yoon1, 2 & Nicholas Gaiano1, 2, 3, 4

1  Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

2  Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

3  Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

4  Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Correspondence should be addressed to Nicholas Gaiano gaiano@jhmi.edu
The Notch pathway, although originally identified in fruit flies, is now among the most heavily studied in mammalian biology. In mice, loss-of-function and gain-of-function work has demonstrated that Notch signaling is essential both during development and in the adult in a multitude of tissues. Prominent among these is the CNS, where Notch has been implicated in processes ranging from neural stem cell regulation to learning and memory. Here we review the role of Notch in the mammalian CNS by focusing specifically on mutations generated in mice. These mutations have provided critical insight into Notch function in the CNS and have led to the identification of promising new directions that are likely to generate important discoveries in the future.

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Nature Neuroscience
ISSN: 1097-6256
EISSN: 1546-1726
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