1
Kevin Staley is at the Departments of Pediatrics and Neurology, University of Colorado Health Sciences Center, Denver, Colorado, USA. kevin.staley@uchsc.edu
2
Helen Scharfman is at the Departments of Pharmacology and Neurology, Columbia University, New York, New York, USA and the Center for Neural Recovery and Rehabilitation Research (CNRRR), Helen Hayes Hospital, New York State Department of Health, West Haverstraw, New York, USA.
Hormonal changes during the estrous cycle have profound effects on synaptic transmission, from altering the density of synapses to changing receptor composition. A new paper shows that neurons express different subsets of GABAA receptor subunits during different phases of the estrous cycle, and that this alters tonic inhibition, seizure susceptibility and anxiety in female mice.
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