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Finding the G spot on fusion machinery

Nature Neuroscience volume 8, pages 542–544 (2005)Cite this article

Activation of G protein–coupled receptors can inhibit secretion of neurotransmittters and hormones. Two recent reports in Nature Neuroscience show that this inhibition is due to Gβγ binding to SNAP-25, directly blocking the vesicle fusion machinery.

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Figure 1: Gβγ binding to the C terminus of SNAP-25 directly inhibits release.

Ivelisse Robles

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Authors and Affiliations

  1. Department of Physiology and Biophysics, University of Washington School of Medicine, Box 357290, Seattle, 98195, Washington, USA

    Jane Sullivan

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  1. Jane Sullivan
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Sullivan, J. Finding the G spot on fusion machinery. Nat Neurosci 8, 542–544 (2005). https://doi.org/10.1038/nn0505-542

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