Nature Neuroscience8, 411 - 412 (2005)
Published online: 20 March 2005; | doi:10.1038/nn1431
CaMKII autophosphorylation contributes to rapid learning but is not necessary for memory
Elaine E Irvine, Jeffrey Vernon
& K Peter Giese
Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK.
Correspondence should be addressed to K Peter Giese p.giese@ucl.ac.uk
Autophosphorylation of calcium−calmodulin-dependent kinase II (CaMKII) has been proposed to be the key event in memory storage. We tested this hypothesis with autophosphorylation-deficient mutant mice in hippocampus- and amygdala-dependent learning and memory tasks and found that the autophosphorylation of CaMKII was required for rapid learning but was not essential for memory. We conclude that CaMKII autophosphorylation contributes to single-trial learning but is dispensable for memory.
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CaMKII autophosphorylation contributes to rapid learning but is not necessary for memory
calcium−calmodulin-dependent kinase II (
