Julie A. Kauer is at the Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, MPPB Box G B4, Providence, Rhode Island 02192, USA. Julie_Kauer@brown.edu
How activity-dependent synaptic plasticity shapes the development of inhibitory synapses has remained unclear. In this issue, Gillespie et al. show that in the developing rat auditory system, inhibitory synapses transiently co-release glutamate. The consequent activation of postsynaptic NMDA receptors may be critical for the plasticity mechanisms that determine tonotopic sharpening.
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