Nature Neuroscience 8, 1657 - 1659 (2005)
Published online: 13 November 2005; | doi:10.1038/nn1586
NMDA receptor–independent long-term depression correlates with successful aging in ratsHey-Kyoung Lee1, 2, 3, 4, Sun Seek Min1, 2, 4, Michela Gallagher2
& Alfredo Kirkwood11
Department of Neuroscience, The Mind/Brain Institute, Baltimore, Maryland 21218, USA. 2
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA. 3
Present address: Department of Biology, Neuroscience and Cognitive Science (NACS) Program, University of Maryland, College Park, Maryland 20742, USA. 4
These authors contributed equally to this work.
Correspondence should be addressed to Michela Gallagher michela@jhu.edu or Alfredo Kirkwood kirkwood@jhu.edu Some individuals maintain high cognitive functioning at older ages. Here we show that mechanisms for long-term depression differ in aged rodents that maintain cognitive performance compared to young adults. Our results imply that cognitive abilities may be sustained in aged individuals by a switch in synaptic plasticity mechanisms.
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