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Nature Neuroscience 8, 1633 - 1634 (2005)
doi:10.1038/nn1205-1633

Flipping the switch from electrical to chemical communication

Karl Kandler1 & Edda Thiels1

  1. Karl Kandler and Edda Thiels are in the Department of Neurobiology and Center for the Neuronal Basis of Cognition, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, Pennsylvania 15261, USA. e-mail: kkarl@neurobio.pitt.edu or e-mail: thiels@neurobio.pitt.edu


Immature neurons in many brain regions are electrically coupled through gap junctions, which are lost as chemical synaptic transmission matures. This developmental uncoupling is now shown to require NMDA receptor activation.

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