Nature Neuroscience 8, 1633 - 1634 (2005)
doi:10.1038/nn1205-1633
Flipping the switch from electrical to chemical communicationKarl Kandler
& Edda Thiels
Karl Kandler and Edda Thiels are in the Department of Neurobiology and Center for the Neuronal Basis of Cognition, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, Pennsylvania 15261, USA. kkarl@neurobio.pitt.edu or
thiels@neurobio.pitt.edu
Immature neurons in many brain regions are electrically coupled through gap junctions, which are lost as chemical synaptic transmission matures. This developmental uncoupling is now shown to require NMDA receptor activation.
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