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| This focus contains a series of specially commissioned reviews and perspectives on the neurobiology of drug abuse, decision making and habit formation, as well as a commentary on how these basic science insights should guide public policy on addiction and its treatment. Thanks to generous support from our sponsors, the National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, this focus will be freely available online through January 2006. |
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| Editorial | Top |
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Taking addiction research into the clinic p1413
doi:10.1038/nn1105-1413
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(73K)
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| Book Review | Top |
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Synaptic transmission makes history p1415
Reviewed by: Nicholas C Spitzer
doi:10.1038/nn1105-1415
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(63K)
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| News and Views | Top |
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How neurons keep in touch pp1417 - 1418
Fekrije Selimi
& Nathaniel Heintz
doi:10.1038/nn1105-1417
Abstract | Full text | PDF
(188K)
See also: Article by Hirai et al. |
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Synaptic plasticity and self-organization in the hippocampus pp1418 - 1420
György Buzsáki
& James J Chrobak
doi:10.1038/nn1105-1418
Abstract | Full text | PDF
(143K)
See also: Article by Behrens et al. |
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Glial cells under remote control pp1420 - 1422
Klaus-Armin Nave
& Markus H Schwab
doi:10.1038/nn1105-1420
Abstract | Full text | PDF
(737K)
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Senseless makes sense for spinocerebellar ataxia-1 pp1422 - 1424
Vikram Khurana, Tudor A Fulga
& Mel B Feany
doi:10.1038/nn1105-1422
Abstract | Full text | PDF
(252K)
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How the brain recovers following damage pp1424 - 1425
Yalçin Abdullaev
& Michael I Posner
doi:10.1038/nn1105-1424
Abstract | Full text | PDF
(169K)
See also: Article by Corbetta et al. |
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Time to smell the roses p1425
Cara Allen
doi:10.1038/nn1105-1425
Full text | PDF
(108K)
See also: Article by Brown et al. |
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| Introduction | Top |
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Focus on Neurobiology of addiction
Neurobiology of addiction p1427
I-han Chou
& Kalyani Narasimhan
doi:10.1038/nn1105-1427
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(82K)
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| Sponsor's Foreword | Top |
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Focus on Neurobiology of addiction
The neuroscience of addiction pp1429 - 1430
Nora Volkow
& Ting-Kai Li
doi:10.1038/nn1105-1429
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(116K)
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| Commentaries | Top |
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Focus on Neurobiology of addiction
Neurobiology of addiction: treatment and public policy ramifications pp1431 - 1436
Charles Dackis
& Charles O'Brien
doi:10.1038/nn1105-1431
Abstract | Full text | PDF
(232K)
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Focus on Neurobiology of addiction
The role of neuroadaptations in relapse to drug seeking pp1437 - 1439
Yavin Shaham
& Bruce T Hope
doi:10.1038/nn1105-1437
Abstract | Full text | PDF
(86K)
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Focus on Neurobiology of addiction
How do we determine which drug-induced neuroplastic changes are important? pp1440 - 1441
Peter W Kalivas
doi:10.1038/nn1105-1440
Abstract | Full text | PDF
(74K)
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Focus on Neurobiology of addiction
Plasticity of reward neurocircuitry and the 'dark side' of drug addiction pp1442 - 1444
George F Koob
& Michel Le Moal
doi:10.1038/nn1105-1442
Abstract | Full text | PDF
(89K)
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| Perspectives | Top |
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Focus on Neurobiology of addiction
Is there a common molecular pathway for addiction? pp1445 - 1449
Eric J Nestler
Published online: 26 October 2005 | doi:10.1038/nn1578
Abstract | Full text | PDF
(247K)
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Focus on Neurobiology of addiction
Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction pp1450 - 1457
Mary Jeanne Kreek, David A Nielsen, Eduardo R Butelman
& K Steven LaForge
Published online: 26 October 2005 | doi:10.1038/nn1583
Abstract | Full text | PDF
(250K)
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Focus on Neurobiology of addiction
Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective pp1458 - 1463
Antoine Bechara
Published online: 26 October 2005 | doi:10.1038/nn1584
Abstract | Full text | PDF
(195K)
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| Reviews | Top |
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Focus on Neurobiology of addiction
Nicotine addiction and comorbidity with alcohol abuse and mental illness pp1465 - 1470
John A Dani
& R Adron Harris
Published online: 26 October 2005 | doi:10.1038/nn1580
Abstract | Full text | PDF
(216K)
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Focus on Neurobiology of addiction
Laboratory models of alcoholism: treatment target identification and insight into mechanisms pp1471 - 1480
David M Lovinger
& John C Crabbe
Published online: 26 October 2005 | doi:10.1038/nn1581
Abstract | Full text | PDF
(596K)
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Focus on Neurobiology of addiction
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion pp1481 - 1489
Barry J Everitt
& Trevor W Robbins
Published online: 26 October 2005 | doi:10.1038/nn1579
Abstract | Full text | PDF
(380K)
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| Brief Communications | Top |
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The cerebellum communicates with the basal ganglia pp1491 - 1493
Eiji Hoshi, Léon Tremblay, Jean Féger, Peter L Carras
& Peter L Strick
Published online: 02 October 2005 | doi:10.1038/nn1544
Abstract | Full text | PDF
(242K)
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Shift of activity from attention to motor-related brain areas during visual learning pp1494 - 1496
Stefan Pollmann
& Marianne Maertens
Published online: 02 October 2005 | doi:10.1038/nn1552
Abstract | Full text | PDF
(194K)
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The essential role of stimulus temporal patterning in enabling perceptual learning pp1497 - 1499
Shu-Guang Kuai, Jun-Yun Zhang, Stanley A Klein, Dennis M Levi
& Cong Yu
Published online: 16 October 2005 | doi:10.1038/nn1546
Abstract | Full text | PDF
(135K)
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COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome pp1500 - 1502
Doron Gothelf, Stephan Eliez, Tracy Thompson, Christine Hinard, Lauren Penniman, Carl Feinstein, Hower Kwon, Shuting Jin, Booil Jo, Stylianos E Antonarakis, Michael A Morris
& Allan L Reiss
Published online: 23 October 2005 | doi:10.1038/nn1572
Abstract | Full text | PDF
(118K)
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| Articles | Top |
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MPS-1 is a K+ channel  -subunit and a serine/threonine kinase pp1503 - 1509
Shi-Qing Cai, Leonardo Hernandez, Yi Wang, Ki Ho Park
& Federico Sesti
Published online: 16 October 2005 | doi:10.1038/nn1557
Abstract | Full text | PDF
(406K)
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Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes pp1510 - 1515
Leping Cheng, Omar Abdel Samad, Yi Xu, Rumiko Mizuguchi, Ping Luo, Senji Shirasawa, Martyn Goulding
& Qiufu Ma
Published online: 23 October 2005 | doi:10.1038/nn1569
Abstract | Full text | PDF
(523K)
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The transmembrane semaphorin Sema6A controls cerebellar granule cell migration pp1516 - 1524
Géraldine Kerjan, Jackie Dolan, Cécile Haumaitre, Sylvie Schneider-Maunoury, Hajime Fujisawa, Kevin J Mitchell
& Alain Chédotal
Published online: 02 October 2005 | doi:10.1038/nn1555
Abstract | Full text | PDF
(1,066K)
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TARP  -8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity pp1525 - 1533
Nathalie Rouach, Keith Byrd, Ronald S Petralia, Guillermo M Elias, Hillel Adesnik, Susumu Tomita, Siavash Karimzadegan, Colin Kealey, David S Bredt
& Roger A Nicoll
Published online: 09 October 2005 | doi:10.1038/nn1551
Abstract | Full text | PDF
(1,139K)
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Cbln1 is essential for synaptic integrity and plasticity in the cerebellum pp1534 - 1541
Hirokazu Hirai, Zhen Pang, Dashi Bao, Taisuke Miyazaki, Leyi Li, Eriko Miura, Jennifer Parris, Yongqi Rong, Masahiko Watanabe, Michisuke Yuzaki
& James I Morgan
Published online: 23 October 2005 | doi:10.1038/nn1576
Abstract | Full text | PDF
(1,009K)
| Supplementary Information
See also: News and Views by Selimi & Heintz |
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Activity-dependent decrease of excitability in rat hippocampal neurons through increases in Ih pp1542 - 1551
Yuan Fan, Desdemona Fricker, Darrin H Brager, Xixi Chen, Hui-Chen Lu, Raymond A Chitwood
& Daniel Johnston
Published online: 23 October 2005 | doi:10.1038/nn1568
Abstract | Full text | PDF
(3,469K)
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Fine-scale specificity of cortical networks depends on inhibitory cell type and connectivity pp1552 - 1559
Yumiko Yoshimura
& Edward M Callaway
Published online: 09 October 2005 | doi:10.1038/nn1565
Abstract | Full text | PDF
(627K)
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Induction of sharp wave–ripple complexes in vitro and reorganization of hippocampal networks pp1560 - 1567
Christoph J Behrens, Leander P van den Boom, Livia de Hoz, Alon Friedman
& Uwe Heinemann
Published online: 16 October 2005 | doi:10.1038/nn1571
Abstract | Full text | PDF
(430K)
| Supplementary Information
See also: News and Views by Buzsáki & Chrobak |
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Encoding a temporally structured stimulus with a temporally structured neural representation pp1568 - 1576
Stacey L Brown, Joby Joseph
& Mark Stopfer
Published online: 16 October 2005 | doi:10.1038/nn1559
Abstract | Full text | PDF
(4,331K)
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See also: News and Views by Allen |
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Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function pp1577 - 1585
Karen T Chang
& Kyung-Tai Min
Published online: 16 October 2005 | doi:10.1038/nn1564
Abstract | Full text | PDF
(585K)
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Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice pp1586 - 1594
Marta Paterlini, Stanislav S Zakharenko, Wen-Sung Lai, Jie Qin, Hui Zhang, Jun Mukai, Koen G C Westphal, Berend Olivier, David Sulzer, Paul Pavlidis, Steven A Siegelbaum, Maria Karayiorgou
& Joseph A Gogos
Published online: 23 October 2005 | doi:10.1038/nn1562
Abstract | Full text | PDF
(394K)
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Neural correlates of binocular rivalry in the human lateral geniculate nucleus pp1595 - 1602
Klaus Wunderlich, Keith A Schneider
& Sabine Kastner
Published online: 23 October 2005 | doi:10.1038/nn1554
Abstract | Full text | PDF
(359K)
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Neural basis and recovery of spatial attention deficits in spatial neglect pp1603 - 1610
Maurizio Corbetta, Michelle J Kincade, Chris Lewis, Abraham Z Snyder
& Ayelet Sapir
Published online: 23 October 2005 | doi:10.1038/nn1574
Abstract | Full text | PDF
(766K)
| Supplementary Information
See also: News and Views by Abdullaev & Posner |
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Perceptions of moral character modulate the neural systems of reward during the trust game pp1611 - 1618
M R Delgado, R H Frank
& E A Phelps
Published online: 16 October 2005 | doi:10.1038/nn1575
Abstract | Full text | PDF
(259K)
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| Technical Report | Top |
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A hybrid approach to measuring electrical activity in genetically specified neurons pp1619 - 1626
Baron Chanda, Rikard Blunck, Leonardo C Faria, Felix E Schweizer, Istvan Mody
& Francisco Bezanilla
Published online: 02 October 2005 | doi:10.1038/nn1558
Abstract | Full text | PDF
(522K)
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