Senseless makes sense for spinocerebellar ataxia-1
Vikram Khurana, Tudor A Fulga
& Mel B Feany
The authors are at the Department of Pathology at Brigham and Women's Hospital and Harvard Medical School, 77 Louis Pasteur Ave., Boston, Massachusetts 02115, USA. mel_feany@hms.harvard.edu
Why are some neurons selectively targeted for death in neurodegenerative diseases? A recent paper combines genetics in the fruit fly and mouse to uncover mechanisms underlying the vulnerability of Purkinje cells in spinocerebellar ataxia-1.
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