Nature Neuroscience 8, 1417 - 1418 (2005)
doi:10.1038/nn1105-1417
How neurons keep in touchFekrije Selimi1, 2
& Nathaniel Heintz11
Fekrije Selimi and Nathaniel Heintz are at the Laboratory for Molecular Biology, and the Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA. heintz@mail.rockefeller.edu
2
Fekrije Selimi is also at the Centre National de la Recherche Scientifique, UMR7102, Paris, France. Cerebellin 1 is abundant in the cerebellum, but its function remains a mystery. Hirai et al. now show that this gene is required to maintain parallel fiber-Purkinje cell synapses, via the orphan glutamate receptor subunit Grid2. These findings provide further evidence that there is a molecular pathway devoted to maintenance of synapses.
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