Nature Neuroscience
8, 1289 - 1291 (2005)
Published online: 11 September 2005; | doi:10.1038/nn1548
Agouti-related peptide−expressing neurons are mandatory for feedingEva Gropp1, Marya Shanabrough2, Erzsebet Borok2, Allison W Xu3, Ruth Janoschek1, Thorsten Buch4, Leona Plum1, 5, Nina Balthasar6, Brigitte Hampel1, Ari Waisman7, Gregory S Barsh3, Tamas L Horvath2
& Jens C Brüning11
Institute for Genetics and Center for Molecular Medicine (CMMC), Department of Mouse Genetics and Metabolism, University of Cologne, Zülpicher Str. 47, 50674 Köln, Germany. 2
Department of Obstetrics, Gynecology & Reproductive Sciences, Department of Neurobiology and Section of Comparative Medicine, Yale University School of Medicine, 333 Cedar St. FMB 339, New Haven, Connecticut 06520, USA. 3
Department of Genetics and Pediatrics, Stanford University School of Medicine, 279 Campus Drive, Stanford, California 94305, USA. 4
Cellular Immunology, Institute for Genetics, University of Cologne, Zülpicher Str. 47, 50674 Köln, Germany. 5
Second Department of Internal Medicine, University of Cologne, Kerpener Str. 62, 50924 Köln, Germany. 6
Beth Israel Deaconess Medical Center, Division of Endocrinology, Harvard Medical School, 99 Brookline Ave., Boston, Massachusetts 02215, USA. 7
Unit for Pathophysiology, I. Medizinische Klinik und Poliklinik, Johannes-Gutenberg-University Mainz, Obere Zahlbacher Str. 63, 55131 Mainz, Germany.
Correspondence should be addressed to Jens C Brüning jens.bruening@uni-koeln.de or Tamas L Horvath tamas.horvath@yale.edu Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus. Nevertheless, inactivation of the genes encoding NPY and/or AgRP has no impact on food intake in mice. Here we demonstrate that induced selective ablation of AgRP-expressing neurons in adult mice results in acute reduction of feeding, demonstrating direct evidence for a critical role of these neurons in the regulation of energy homeostasis.
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