Nature Neuroscience
8, 1292 - 1294 (2005)
Published online: 28 August 2005; Corrected online: 05 September 2005 | doi:10.1038/nn1532
Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?Eric Burguière1, Angelo Arleo1, 4, Mohammad reza Hojjati2, 3, Ype Elgersma2, Chris I De Zeeuw2, Alain Berthoz1
& Laure Rondi-Reig11
Laboratoire de Physiologie de la Perception et de l'Action, UMR CNRS 7152, 11 place Marcelin Berthelot, Collège de France, 75005 Paris, France. 2
Department of Neuroscience, Erasmus MC, 3000 DR, Rotterdam, The Netherlands. 3
Department of Physiology, Shahrekord University of Medical Sciences, Iran. 4
Present address: Neuroscience Group, Sony Computer Science Laboratory, 6 rue Amyot, 75005 Paris, France.
Correspondence should be addressed to Laure Rondi-Reig laure.rondi-reig@college-de-france.fr L7-PKCI transgenic mice, which lack parallel fiber−Purkinje cell long-term depression (LTD), were tested with two different mazes to dissociate the relative importance of declarative and procedural components of spatial navigation. We show that L7-PKCI mice are deficient in acquisition of an adapted goal-oriented behavior, part of the procedural component of the task. This supports the hypothesis that cerebellar LTD may subserve a general sensorimotor adaptation process shared by motor and spatial learning functions. *Note: In the version of this article initially published online, the third author's name was incorrect. The correct name is Mohammed reza Hojjati. The error has been corrected in the HTML and print versions of the article.
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