A no-Wnt situation: SFRPs as axon guidance molecules
Uwe Drescher
Uwe Drescher is at the MRC Centre for Developmental Neurobiology, King's College London, Guy's Campus, London SE1 1UL, UK. uwe.drescher@kcl.ac.uk
SFRPs are endogenous inhibitors of Wnt signaling. New work shows that, independently of its interaction with Wnts, SFRP1 can act as a repulsive guidance molecule for retinal axons on their way to the tectum, signaling through the receptor Fz2.
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